Article
Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.
PLoS genetics - 1 Aug 2014
Lee Euna, Jeong Eun Hee, Jeong Hyun-Jeong, Yildirim Evrim, Vanselow Jens T, Ng Fanny, Liu Yixiao, Mahesh Guruswamy, Kramer Achim, Hardin Paul E, Edery Isaac, Kim Eun Young
Abstract excerpt
Transcriptional/translational feedback loops drive daily cycles of expression in clock genes and clock-controlled genes, which ultimately underlie many of the overt circadian rhythms manifested by organisms. Moreover, phosphorylation of clock proteins plays crucial roles in the temporal regulatio...
Topics
- Alanine
- Animals
- CLOCK Proteins
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Mutation
- Phosphorylation
- RNA, Messenger