Article

Casein Kinase 1 dynamics underlie the PER2 circadian phosphoswitch

2019-08-14

Abstract excerpt

<h4>Summary</h4> Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the factors that influence substrate selectivity on functionally antagonistic sites in PERIOD that directly control circadian period. Here we describe a mo...

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Literature Corpus work: 49a4d2d0-b5d8-52aa-9738-055a03e88de0
DOI: 10.1101/734624

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