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Article

Casein kinase 1 promotes synchrony of the circadian clock network.

Molecular and cellular biology - 1 Jul 2014

Zheng Xiangzhong, Sowcik Mallory, Chen Dechun, Sehgal Amita

Abstract excerpt

Casein kinase 1, known as DOUBLETIME (DBT) in Drosophila melanogaster, is a critical component of the circadian clock that phosphorylates and promotes degradation of the PERIOD (PER) protein. However, other functions of DBT in circadian regulation are not clear, in part because severe reduction of dbt causes preadult lethality. Here we report the molecular and behavioral phenotype of a viable dbt(EY02910)...

Topics

Animals
Brain
CLOCK Proteins
Casein Kinase 1 epsilon
Circadian Clocks
Circadian Rhythm
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation
Mutation
Period Circadian Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 24820422
DOI: 10.1128/MCB.01571-13
PMCID: PMC4097653

Genes

DBT
CLOCK
PDF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24820422-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Casein kinase 1 promotes synchrony of the circadian clock network.PMID 24820422Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.Semantic proximity Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

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