Article
Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.
Molecular and cellular biology - 1 Dec 2007
Muskus Michael J, Preuss Fabian, Fan Jin-Yuan, Bjes Edward S, Price Jeffrey L
Abstract excerpt
A mutation (K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt]). In vitro, DBT protein carrying the K38R mutation (DBT(K/R)) interacted with Period protein (PER) but lacked kinase activity. In cell culture and in flies, DBT(K/...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Arginine
- Behavior, Animal
- Casein Kinase 1 epsilon
- Catalysis
- Cell Nucleus
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression
- Genes, Dominant
- Larva
- Lysine
- Molecular Sequence Data
- Motor Activity
- Mutant Proteins