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Article

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.

Molecular and cellular biology - 1 Dec 2007

Muskus Michael J, Preuss Fabian, Fan Jin-Yuan, Bjes Edward S, Price Jeffrey L

Abstract excerpt

A mutation (K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt]). In vitro, DBT protein carrying the K38R mutation (DBT(K/R)) interacted with Period protein (PER) but lacked kinase activity. In cell culture and in flies, DBT(K/R) antagonized the phosphorylation and degradation of PER, and it damped the oscillation of PER in vivo. Overexpression...

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Identifiers

PMID: 17893330
DOI: 10.1128/MCB.00680-07
PMCID: PMC2169192

Genes

DBT

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.PMID 17893330Read ↗

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