Article
Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.
Molecular and cellular biology - 1 Jan 2004
Preuss Fabian, Fan Jin-Yuan, Kalive Madhavi, Bao Shu, Schuenemann Eric, Bjes Edward S, Price Jeffrey L
Abstract excerpt
In both mammals and fruit flies, casein kinase I has been shown to regulate the circadian phosphorylation of the period protein (PER). This phosphorylation regulates the timing of PER's nuclear accumulation and decline, and it is necessary for the generation of circadian rhythms. In Drosophila melanogaster, mutations affecting a casein kinase I (CKI) ortholog called doubletime (dbt) can produce short or long...
Topics
- Animals
- Base Sequence
- Casein Kinases
- Cell Line
- Circadian Rhythm
- DNA
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Insect
- In Vitro Techniques
- Mutagenesis, Site-Directed