Article
Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.
Genetics - 1 Jan 2009
Fan Jin-Yuan, Preuss Fabian, Muskus Michael J, Bjes Edward S, Price Jeffrey L
Abstract excerpt
Mutations lowering the kinase activity of Drosophila Doubletime (DBT) and vertebrate casein kinase Iepsilon/delta (CKIepsilon/delta) produce long-period, short-period, and arrhythmic circadian rhythms. Since most ckI short-period mutants have been isolated in mammals, while the long-period mutant...
Topics
- Animals
- Animals, Genetically Modified
- Casein Kinase 1 epsilon
- Casein Kinase Idelta
- Circadian Rhythm
- Conserved Sequence
- Drosophila Proteins
- Drosophila melanogaster
- Evolution, Molecular
- Genotype
- Isoenzymes
- Motor Activity
- Mutant Proteins
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Phosphoprotein Phosphatases
- Phosphorylation