Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.

Genetics - 1 Jan 2009

Fan Jin-Yuan, Preuss Fabian, Muskus Michael J, Bjes Edward S, Price Jeffrey L

Abstract excerpt

Mutations lowering the kinase activity of Drosophila Doubletime (DBT) and vertebrate casein kinase Iepsilon/delta (CKIepsilon/delta) produce long-period, short-period, and arrhythmic circadian rhythms. Since most ckI short-period mutants have been isolated in mammals, while the long-period mutants have been found mostly in Drosophila, lowered kinase activity may have opposite consequences in flies and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Isoenzymes

Share to Mutation

Share to Nuclear Proteins

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 18957703
DOI: 10.1534/genetics.108.094805
PMCID: PMC2621163

Genes

DBT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.PMID 18957703Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.Semantic proximity Read ↗

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.Semantic proximity Read ↗

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Semantic proximity Read ↗

Activating PER repressor through a DBT-directed phosphorylation switch.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.Semantic proximity Read ↗

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

Casein kinase I: another cog in the circadian clockworks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.