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Article

A role for casein kinase 2alpha in the Drosophila circadian clock.

Nature - 1 Jan 2000

Lin Jui-Ming, Kilman Valerie L, Keegan Kevin, Paddock Brie, Emery-Le Myai, Rosbash Michael, Allada Ravi

Abstract excerpt

Circadian clocks drive rhythmic behaviour in animals and are regulated by transcriptional feedback loops. For example, the Drosophila proteins Clock (Clk) and Cycle (Cyc) activate transcription of period (per) and timeless (tim). Per and Tim then associate, translocate to the nucleus, and repress the activity of Clk and Cyc. However, post-translational modifications are also critical to proper timing. Per and Tim...

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PMID: 12447397
DOI: 10.1038/nature01235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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