Article
A role for casein kinase 2alpha in the Drosophila circadian clock.
Nature - 1 Jan 2000
Lin Jui-Ming, Kilman Valerie L, Keegan Kevin, Paddock Brie, Emery-Le Myai, Rosbash Michael, Allada Ravi
Abstract excerpt
Circadian clocks drive rhythmic behaviour in animals and are regulated by transcriptional feedback loops. For example, the Drosophila proteins Clock (Clk) and Cycle (Cyc) activate transcription of period (per) and timeless (tim). Per and Tim then associate, translocate to the nucleus, and repress...
Topics
- Active Transport, Cell Nucleus
- Animals
- Biological Clocks
- Blotting, Western
- Casein Kinase II
- Cell Nucleus
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Insect Proteins
- Motor Activity
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Phenotype
- Phosphorylation
- Protein Serine-Threonine Kinases