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Article

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.

PLoS genetics - 1 Jan 2013

Garbe David S, Fang Yanshan, Zheng Xiangzhong, Sowcik Mallory, Anjum Rana, Gygi Steven P, Sehgal Amita

Abstract excerpt

Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several kinases and phosphatases such as Protein Phosphatase-2A (PP2A) and Protein Phosphatase-1 (PP1). Here, we used mass spectrometry to identify 35 "phospho-occupied" serine/threonine residues within...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24086144
DOI: 10.1371/journal.pgen.1003749
PMCID: PMC3784489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.PMID 24086144Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

PERspective on PER phosphorylation.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.Semantic proximity Read ↗

An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.Semantic proximity Read ↗

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

Temporal phosphorylation of the Drosophila period protein.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

Activating PER repressor through a DBT-directed phosphorylation switch.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

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