Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.

doi:10.1371/journal.pgen.1003749

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Article

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.

PLoS genetics - 1 Jan 2013

Garbe David S, Fang Yanshan, Zheng Xiangzhong, Sowcik Mallory, Anjum Rana, Gygi Steven P, Sehgal Amita

Abstract excerpt

Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several kinases and phosphatases such as Protein Phosphatase-2A (PP2A) and Protein Phos...

Topics

Animals
Circadian Rhythm
Drosophila Proteins
Drosophila melanogaster
Humans
Mutation
Period Circadian Proteins
Phenotype
Phosphorylation
Protein Phosphatase 1
Protein Phosphatase 2

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