Article

Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis

2024-02-01

Abstract excerpt

Fibrosis is a chronic disease characterized by excessive extracellular matrix (ECM) production which leads to destruction of normal tissue architecture and disruption of organ function. Fibroblasts are key effector cells of this process and respond to a host of pro-fibrotic stimuli, including notably the pleiotropic cytokine, TGF-β 1 , which promotes fibroblast to myofibroblast differentiation. This is accompanie...

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Literature Corpus work: 067e2992-a773-5c57-b80b-448fcb9f49d5
DOI: 10.1101/2024.01.30.577965

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