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Article

Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2017

Xie Na, Cui Huachun, Ge Jing, Banerjee Sami, Guo Sijia, Dubey Shubham, Abraham Edward, Liu Rui-Ming, Liu Gang

Abstract excerpt

Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis. However, systematic characterization of expression profile in these cells is still lacking. Furthermore, main metabolic programs and their regulation of cellular phenotype are completely unknown. In this study, we comprehensively...

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Identifiers

PMID: 28798256
DOI: 10.1152/ajplung.00235.2017
PMCID: PMC5792180

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