Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.

Future medicinal chemistry - 1 Jan 2017

Katt William P, Lukey Michael J, Cerione Richard A

Abstract excerpt

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Enzyme Inhibitors
Share to Glutaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 28111979
DOI: 10.4155/fmc-2016-0190
PMCID: PMC5558546

Genes

GLS
GLS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.PMID 28111979Read ↗

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic CancerSemantic proximity Read ↗

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2Semantic proximity Read ↗

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.Semantic proximity Read ↗

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.Semantic proximity Read ↗

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cellsSemantic proximity Read ↗

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.Semantic proximity Read ↗

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.Semantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

A pan-cancer analysis of the glutaminase and their association with prognosis, tumor microenvironment, and therapeutic targetsSemantic proximity Read ↗

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian CellsSemantic proximity Read ↗

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.Semantic proximity Read ↗

Metabolic Signaling Cascades Prompted by Glutaminolysis in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.