Article
Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types.
Cellular and molecular life sciences : CMLS - 1 Dec 2021
Umar Sadiq, Palasiewicz Karol, Volin Michael V, Romay Bianca, Rahat Rani, Tetali Chandana, Arami Shiva, Guma Monica, Ascoli Christian, Sweiss Nadera, Zomorrodi Ryan K, O'Neill Luke A J, Shahrara Shiva
Abstract excerpt
Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function. Yet, the metabolic reconfiguration of RA macrophages (MΦs) is incompletely understood during active disease and in crosstalk with other cell types in experimental arthritis. This study elucidates a distinct regulation of glycolysis and oxidative phosphorylation in RA MΦs compared to fibroblast (FLS),...
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