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Article

Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis.

Molecular metabolism - 1 Jan 2023

Xiang Zheyi, Bai Le, Zhou Jennifer Q, Cevallos Ricardo R, Sanders Jonathan R, Liu Gang, Bernard Karen, Sanders Yan Y

Abstract excerpt

OBJECTIVE: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts glutamine to glutamate. Here, we investigated the role of glutaminolysis and glutaminolysis-derived metabolite...

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Share to Epigenesis, Genetic
Share to Fibroblasts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36526153
DOI: 10.1016/j.molmet.2022.101655
PMCID: PMC9827063

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