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Article

TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts.

Scientific reports - 21 Oct 2020

Smith Edward R, Hewitson Timothy D

Abstract excerpt

TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate dehydrogenase complex (PDC). Flow cytometry showed that TGF-β1 reduced the PDC subunit PDH-E1α in fibroblasts derived from injured, but...

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Source

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Identifiers

PMID: 33087819
DOI: 10.1038/s41598-020-74919-8
PMCID: PMC7578649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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