Article

Integrative statistical methods for the genomic analysis of immune-mediated disease

2020-01-01

Abstract excerpt

Genome-wide association studies (GWAS) have proved to be a successful method in cataloguing loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such associations has proved challenging due to the regulatory nature of the majority of signals. In Chapters 2 and 3, I hypothesised that promoter-capture Hi-C (PCHi-C) data might have utility in physically...

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Literature Corpus work: 828e3b01-5737-5fd9-86d1-16430ed77fb3
DOI: 10.17863/cam.48342

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