Article

Characterising the gene regulatory landscape of CD4+ T cells

2019-01-01

Abstract excerpt

Despite the high prevalence of immune-mediated diseases, the molecular mechanisms by which they arise and the influence of genetic variation in the predisposition to disease are not well understood. Immune susceptibility loci identified by genome wide association studies (GWAS) overlap with active regulatory elements in CD4+ T cells, and particularly in regulatory T cells (Tregs). CD4+ T cells are the orchestrator...

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Literature Corpus work: 78a53422-1af5-5c99-befa-f3784e5a941c
DOI: 10.17863/cam.39595

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