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Article

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

PLoS genetics - 1 Jun 2014

Hu Xinli, Kim Hyun, Raj Towfique, Brennan Patrick J, Trynka Gosia, Teslovich Nikola, Slowikowski Kamil, Chen Wei-Min, Onengut Suna, Baecher-Allan Clare, De Jager Philip L, Rich Stephen S, Stranger Barbara E, Brenner Michael B, Raychaudhuri Soumya

Abstract excerpt

Genome-wide association studies (GWAS) and subsequent dense-genotyping of associated loci identified over a hundred single-nucleotide polymorphism (SNP) variants associated with the risk of rheumatoid arthritis (RA), type 1 diabetes (T1D), and celiac disease (CeD). Immunological and genetic studies suggest a role for CD4-positive effector memory T (CD+ TEM) cells in the pathogenesis of these diseases. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

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Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 24968232
DOI: 10.1371/journal.pgen.1004404
PMCID: PMC4072514

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