Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.

Abstract excerpt

Although genome-wide association studies have implicated many individual loci in complex diseases, identifying the exact causal alleles and the cell types within which they act remains greatly challenging. To ultimately understand disease mechanism, researchers must carefully conceive functional studies in relevant pathogenic cell types to demonstrate the cellular impact of disease-associated genetic variants....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arthritis, Rheumatoid
• Share to Autoimmune Diseases