Article
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.
Cell - 17 Nov 2016
Chen Lu, Ge Bing, Casale Francesco Paolo, Vasquez Louella, Kwan Tony, Garrido-Martín Diego, Watt Stephen, Yan Ying, Kundu Kousik, Ecker Simone, Datta Avik, Richardson David, Burden Frances, Mead Daniel, Mann Alice L, Fernandez Jose Maria, Rowlston Sophia, Wilder Steven P, Farrow Samantha, Shao Xiaojian, Lambourne John J, Redensek Adriana, Albers Cornelis A, Amstislavskiy Vyacheslav, Ashford Sofie, Berentsen Kim, Bomba Lorenzo, Bourque Guillaume, Bujold David, Busche Stephan, Caron Maxime, Chen Shu-Huang, Cheung Warren, Delaneau Oliver, Dermitzakis Emmanouil T, Elding Heather, Colgiu Irina, Bagger Frederik O, Flicek Paul, Habibi Ehsan, Iotchkova Valentina, Janssen-Megens Eva, Kim Bowon, Lehrach Hans, Lowy Ernesto, Mandoli Amit, Matarese Filomena, Maurano Matthew T, Morris John A, Pancaldi Vera, Pourfarzad Farzin, Rehnstrom Karola, Rendon Augusto, Risch Thomas, Sharifi Nilofar, Simon Marie-Michelle, Sultan Marc, Valencia Alfonso, Walter Klaudia, Wang Shuang-Yin, Frontini Mattia, Antonarakis Stylianos E, Clarke Laura, Yaspo Marie-Laure, Beck Stephan, Guigo Roderic, Rico Daniel, Martens Joost H A, Ouwehand Willem H, Kuijpers Taco W, Paul Dirk S, Stunnenberg Hendrik G, Stegle Oliver, Downes Kate, Pastinen Tomi, Soranzo Nicole
Abstract excerpt
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types (CD14+ monocytes, CD16+ neutrophils, and naive CD4+ T cells) from up to 197 individuals. We assess, quantitatively, the relative contribution...
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