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Article

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

Nature communications - 1 Jan 2013

Fugger Kasper, Chu Wai Kit, Haahr Peter, Kousholt Arne Nedergaard, Beck Halfdan, Payne Miranda J, Hanada Katsuhiro, Hickson Ian D, Sørensen Claus Storgaard

Abstract excerpt

The molecular events occurring following the disruption of DNA replication forks are poorly characterized, despite extensive use of replication inhibitors such as hydroxyurea in the treatment of malignancies. Here, we identify a key role for the FBH1 helicase in mediating DNA double-strand break formation following replication inhibition. We show that FBH1-deficient cells are resistant to killing by hydroxyurea,...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23361013
DOI: 10.1038/ncomms2395

Genes

FBH1
MUS81
EME1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.PMID 23361013Read ↗

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Semantic proximity Read ↗

Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.Semantic proximity Read ↗

Bloom's Syndrome Helicase and Mus81 are Required to Induce Transient Double-strand DNA Breaks in Response to DNA Replication StressSemantic proximity Read ↗

FBH1 protects melanocytes from transformation and is deregulated in melanomas.Semantic proximity Read ↗

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiencySemantic proximity Read ↗

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathwaySemantic proximity Read ↗

Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumorsSemantic proximity Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexesSemantic proximity Read ↗

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.Semantic proximity Read ↗

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanismSemantic proximity Read ↗

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.Semantic proximity Read ↗

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