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PARP1 UFMylation ensures the stability of stalled replication forks

24 Apr 2024

Abstract excerpt

The S-phase checkpoint involving CHK1 is essential for fork stability in response to fork stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation. However, it is unclear how the activity of PARP1 is regulated. Here, we found that UFMylation is required for the efficient activation of CHK1 by UFMylating PARP1 at K548 during replication stress. Inactivation of UFL1, the E3 enzyme...

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PMID: 38657044
DOI: 10.1073/pnas.2322520121

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