Article

Differential TCR Signaling and the Mechanics of Autoimmune Escape: A Type 1 Diabetes Paradigm

2026-07-31

Abstract excerpt

We deduce generic principles of autoimmunity and antigen immunogenicity by extending the Differential TCR Signaling Model with a mechanophysical framework of differential mechanical displacement, using Type 1 Diabetes (T1D) as a paradigm. In this synthesis, we analyzed published structural, biophysical (peptide-MHC binding affinity), and clinical (longitudinal autoantibody) data through the lens of this extended m...

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Literature Corpus work: 0576947a-56ee-5805-879b-ca1890954194
DOI: 10.14293/pr2199.004176.v1

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