Article

A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes

2024-11-11

Abstract excerpt

<h4>ABSTRACT</h4> The evolving antigenic landscape of autoimmune diabetes reflects a dynamic failure to preserve self-tolerance. Yet, how novel neoantigens emerge in humans remains incompletely understood. Here, we designed an immunopeptidomics-based approach to probe HLA-II-bound, islet-derived neoepitopes in patients with type 1 diabetes (T1D). We uncovered a microenvironment-driven Cys→Ser transformation, cons...

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Literature Corpus work: e0d000ed-5d04-57d6-b90b-c20ae6e659ef
DOI: 10.1101/2024.11.07.622538

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