The beta cell-immune cell interface in type 1 diabetes (T1D)

doi:10.1016/j.molmet.2023.101809

Article

The beta cell-immune cell interface in type 1 diabetes (T1D)

19 Sept 2023

Abstract excerpt

BACKGROUND: T1D is an autoimmune disease in which pancreatic islets of Langerhans are infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta cells. Our understanding of the factors leading to islet infiltration and the interplay of the immune cells with target beta cells is incomplete, especially in human disease. While murine models of T1D have provided crucial...

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