Article

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses

2026-02-12

Abstract excerpt

<h4>Aims/hypothesis</h4> Type 1 diabetes is a complex autoimmune disorder in which autoreactive CD4⁺ and CD8⁺ T cells destroy pancreatic beta-cells, resulting in insulin deficiency and hyperglycemia. Although genetic susceptibility, particularly certain HLA alleles, contributes to disease risk, not all genetically predisposed individuals develop Type 1 diabetes. Screening first degree relatives (FDRs) for islet a...

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Literature Corpus work: 7b9b3e0d-a74e-5a7b-86b4-cc2941508b14
DOI: 10.64898/2026.02.10.705171

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