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Article

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Diabetologia - 1 Oct 2020

Mallone Roberto, Eizirik Decio L

Abstract excerpt

It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, circulate at similar frequencies in type 1 diabetic and healthy individuals. Hence a universal...

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Identifiers

PMID: 32894310
DOI: 10.1007/s00125-020-05176-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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