Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Abstract excerpt

Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are near absent in autoantibody-positive donors, the variable insulitis and residual beta cells of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age of Onset
• Share to Autoimmunity
• Share to CD8-Positive T-Lymphocytes