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Article

Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies

7 May 2024

Abstract excerpt

Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we test the hypothesis that children who later develop clinical disease have different early immune responses, depending on the type of the first autoantibody to appear...

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PMID: 38714671
DOI: 10.1038/s41467-024-47918-w

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