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Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression

20 Mar 2019

Abstract excerpt

Multiple studies of B- and T-cell compartments and their response to stimuli demonstrate alterations in established type 1 diabetes (T1D). Yet it is not known whether these alterations reflect immune mechanisms that initiate islet autoimmunity, promote disease progression, or are secondary to disease. To address these questions, we used samples from the TrialNet Pathway to Prevention study to investigate T-cell...

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PMID: 30894366
DOI: 10.2337/db18-1081

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