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Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

15 May 2016

Abstract excerpt

The cross-reactivity of T cells with pathogen- and self-derived peptides has been implicated as a pathway involved in the development of autoimmunity. However, the mechanisms that allow the clonal T cell antigen receptor (TCR) to functionally engage multiple peptide-major histocompatibility complexes (pMHC) are unclear. Here, we studied multiligand discrimination by a human, preproinsulin reactive, MHC...

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PMID: 27183389
DOI: 10.1172/jci85679

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