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Article

Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis.

Nature microbiology - 1 Jun 2026

Eckartt Kathryn A, Munsamy-Govender Vanisha, Quiñones-Garcia Stefany, DeJesus Michael A, Ju Xiangwu, Liu Shixin, Rock Jeremy M

Abstract excerpt

Mycobacterium tuberculosis (Mtb) acquires resistance to rifampicin (Rif) through mutations in the β-subunit of RNA polymerase (RNAP) that prevent the drug from binding. The most common mutation is a single amino acid substitution, βS450L, that confers antibiotic resistance. This mutation also results in collateral effects that impact bacterial physiology and fitness, although the mechanisms underlying many of...

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Share to Amino Acid Substitution
Share to Amino Acids, Branched-Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibiotics, Antitubercular

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

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Source

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Identifiers

PMID: 42156950
DOI: 10.1038/s41564-026-02357-9
PMCID: PMC13236596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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