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Article

Evolutionary dynamics of drug resistance in MDR-TB: Heterogeneous minor variants and extensive compensatory mutations.

International journal of medical microbiology : IJMM - 1 Jun 2026

Chen Lei, Pei Shaojun, Yu Chunqi, Han Aizhen, Wang Jichun, Zhang Bo, Cao Linna, Cheng Huiyun, Zhao Bing, Zhao Yanlin, Ou Xichao

Abstract excerpt

Multidrug-resistant Mycobacterium tuberculosis complex (MTBC) remains a major global health challenge, yet the drug-specific evolutionary pathways through which resistance accumulates are not fully understood. Heterogeneous minor resistant variants (hSNPs) and compensatory mutations are increasingly recognized as important drivers of the emergence, stability, and transmission of drug-resistant strains. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42119394
DOI: 10.1016/j.ijmm.2026.151714

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EMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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