Back to search

Article

Rifampicin exposure reveals within-host <i>Mycobacterium tuberculosis</i> diversity in patients with delayed culture conversion

2020-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis (Mtb) genetic micro-diversity in clinical isolates may underline mycobacterial adaptive response during the course of tuberculosis (TB) and provide insights to anti-TB treatment response and emergence of resistance. Herein we followed within-host evolution of Mtb clinical isolates in a cohort of patients with delayed Mtb culture conversion. We captured the genetic dive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
738cb47c-727e-5d7a-92a5-410418f8489e
DOI
10.1101/2020.05.22.110775
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Rifampicin exposure reveals within-host <i>Mycobacterium tuberculosis</i> diversity in patients with delayed culture conversionDOI 10.1101/2020.05.22.110775
Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion.Semantic proximity
In-host population dynamics of <i>M. tuberculosis</i> during treatment failureSemantic proximity
Within-host pathogen population diversity predicts treatment response in TuberculosisSemantic proximity
Within-host genetic micro-diversity of <i>Mycobacterium tuberculosis</i> and the link with tuberculosis disease featuresSemantic proximity
<i>In host</i> mutational adaptation of <i>Mycobacterium tuberculosis</i> complex strainsSemantic proximity
Signatures of selection at drug resistance loci in <i>Mycobacterium tuberculosis</i>Semantic proximity
Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung EnvironmentSemantic proximity
Direct transmission of within-host Mycobacterium tuberculosis diversity to secondary cases can lead to variable between-host heterogeneity without de novo mutation: A genomic investigationSemantic proximity
Diversity of <i>Mycobacterium tuberculosis</i> across evolutionary scalesSemantic proximity
In-host population dynamics of Mycobacterium tuberculosis complex during active disease.Semantic proximity
Origin and dynamics of <i>Mycobacterium tuberculosis</i> subpopulations that predictably generate drug tolerance and resistanceSemantic proximity
Intra-host genetic population diversity: Role in emergence and persistence of drug resistance among Mycobacterium tuberculosis complex minor variants.Semantic proximity
Select a neighboring publication to make it the new centre.