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Article

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

Nature communications - 7 May 2026

Pepper-Tunick Evan, Srinivas Vivek, Mast Fred D, Li Song, Russ Sagan, Hanson Weston, Zamora Amy D, Wu Wei-Ju, Silcocks Matthew, Thi Minh Ha Dang, Dunstan Sarah J, Nguyen Thuy Thuong Thuong, Turkarslan Serdar, Aitchison John D, Arrieta-Ortiz Mario L, Baliga Nitin S

Abstract excerpt

The rapid emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) threatens global tuberculosis (TB) control, yet the mechanisms enabling rapid evolution of resistance in Mtb remain poorly understood. Here, we show that pre-existing mutations in oxidative stress response genes create permissive genomic backgrounds that accelerate high-level isoniazid resistance (INHR), challenging the paradigm that...

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Identifiers

PMID: 42098099
DOI: 10.1038/s41467-026-72496-4
PMCID: PMC13153227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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