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Article

Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion.

PLoS pathogens - 1 Jun 2021

Genestet Charlotte, Hodille Elisabeth, Barbry Alexia, Berland Jean-Luc, Hoffmann Jonathan, Westeel Emilie, Bastian Fabiola, Guichardant Michel, Venner Samuel, Lina Gérard, Ginevra Christophe, Ader Florence, Goutelle Sylvain, Dumitrescu Oana

Abstract excerpt

Mycobacterium tuberculosis (Mtb) genetic micro-diversity in clinical isolates may underline mycobacterial adaptation to tuberculosis (TB) infection and provide insights to anti-TB treatment response and emergence of resistance. Herein we followed within-host evolution of Mtb clinical isolates in two cohorts of TB patients, either with delayed Mtb culture conversion (> 2 months), or with fast culture conversion (<...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34166469
DOI: 10.1371/journal.ppat.1009643
PMCID: PMC8224949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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