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Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data

8 Dec 2022

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far. Mendelian randomization (MR) is a genetic method widely used to explore etiologies of complex traits. In the current study, we aimed to identify novel proteins underlying SCZ with a systematic analytical approach. METHODS: We integrated protein quantitative trait loci (pQTLs) of the brain, cerebrospinal fluid (CSF), and...

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PMID: 36482464
DOI: 10.1186/s12916-022-02679-5

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