Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the complement component C4 gene with schizophrenia subphenotypes.

Schizophrenia research - 1 Sept 2024

Chen Cheng C, Howie Joshua, Ebrahimi Mahbod, Teymouri Kowsar, Woo Julia J, Tiwari Arun K, Zai Clement C, Kennedy James L

Abstract excerpt

BACKGROUND: The complement component C4 gene has been identified as a strong marker for schizophrenia (SCZ) risk. The C4 gene has a complex genetic structure consisting of variable structural elements (C4A, C4B, C4L, and C4S) and compound structural forms (C4AL, C4BL, C4AS and C4BS). In addition, the variations in C4 structural forms may have a direct or indirect effect on the brain expression level of C4A and...

Topics

Join the communities discussing this publication.

Age of Onset
Complement C4
Genetic Predisposition to Disease
Phenotype
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychotic Disorders

Sex Characteristics

Source

Identifiers

PMID: 39084106
DOI: 10.1016/j.schres.2024.07.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the complement component C4 gene with schizophrenia subphenotypes.PMID 39084106Read ↗

Schizophrenia risk from complex variation of complement component 4.Semantic proximity Read ↗

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophreniaSemantic proximity Read ↗

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.Semantic proximity Read ↗

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.Semantic proximity Read ↗

Complement component C4 levels in the cerebrospinal fluid and plasma of patients with schizophrenia.Semantic proximity Read ↗

Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary dataSemantic proximity Read ↗

Complement genes contribute sex-biased vulnerability in diverse disorders.Semantic proximity Read ↗

Peripheral Complement C4 Protein in Schizophrenia: Association with Gene Copy Number and Immune Cell SubtypesSemantic proximity Read ↗

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.Semantic proximity Read ↗

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population.Semantic proximity Read ↗

Increased activation product of complement 4 protein in plasma of individuals with schizophrenia.Semantic proximity Read ↗

The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.