Article
The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.
Biological psychiatry - 1 Jul 2011
Håvik Bjarte, Le Hellard Stephanie, Rietschel Marcella, Lybæk Helle, Djurovic Srdjan, Mattheisen Manuel, Mühleisen Thomas W, Degenhardt Franziska, Priebe Lutz, Maier Wolfgang, Breuer Rene, Schulze Thomas G, Agartz Ingrid, Melle Ingrid, Hansen Thomas, Bramham Clive R, Nöthen Markus M, Stevens Beth, Werge Thomas, Andreassen Ole A, Cichon Sven, Steen Vidar M
Abstract excerpt
BACKGROUND: Patients with schizophrenia often suffer from cognitive dysfunction, including impaired learning and memory. We recently demonstrated that long-term potentiation in rat hippocampus, a mechanistic model of learning and memory, is linked to gene expression changes in immunity-related processes involved in complement activity and antigen presentation. We therefore aimed to examine whether key regulators...
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