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Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

2025-05-07

Abstract excerpt

Complement is a key contributor to neuroinflammation, driving pathology in neurodegenerative diseases (NDDs); however, little is known about the source of complement in brain. Effective targeting of complement in NDDs requires understanding of its source; in particular, which brain cells express complement genes, how expression is regulated and how expression changes in disease. To address this knowledge gap, we i...

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Identifiers and source

Literature Corpus work
3f908b29-ff2e-5563-8d6b-2549b0310b94
DOI
10.1101/2025.05.06.652374
Open publication

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Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampusDOI 10.1101/2025.05.06.652374
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