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Iterative Epitope Expansion Enables Structure-Guided <i>de novo</i> Design of IgE-Binding Miniproteins Targeting the Fc <i>ε</i> RI Interface

2025-12-27

Abstract excerpt

Designing de novo protein binders to multidomain assemblies remains challenging due to their structural complexity, conformational diversity, and broad functional epitopes. Here, we present an iterative epitope-expansion strategy that enables structure-guided design of compact miniproteins targeting human immunoglobulin E (IgE). Direct attempts to design binders against the full Fc ε RI-binding interface of IgE...

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Literature Corpus work
044e3c80-8a16-5f97-91ad-bbfb2551a239
DOI
10.64898/2025.12.27.696647
Open publication

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Iterative Epitope Expansion Enables Structure-Guided <i>de novo</i> Design of IgE-Binding Miniproteins Targeting the Fc <i>ε</i> RI InterfaceDOI 10.64898/2025.12.27.696647
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