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Generative design of antibody Fc-variants with synthetic and programmable functional profiles

2025-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Beyond antigen recognition, antibodies direct diverse immune effector functions through their constant (Fc) domain. While the Fc domain is central to antibody biology and therapeutic efficacy, our understanding of how Fc sequence encodes function remains limited, as most of Fc sequence space has not been experimentally mapped or linked to Fc-receptor engagement. Furthermore, the extensive overla...

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Identifiers and source

Literature Corpus work
5e95c4b4-39ea-594a-93bf-9dfae335ad0b
DOI
10.1101/2025.10.10.681689
Open publication

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Generative design of antibody Fc-variants with synthetic and programmable functional profilesDOI 10.1101/2025.10.10.681689
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