Article

Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor Design

2026-05-27

Abstract excerpt

Antigen escape is the dominant mechanism of therapeutic failure in chimeric antigen receptor (CAR) T cell and NK cell therapy, occurring in 30–60% of patients treated with single-target constructs. Existing discovery pipelines select epitopes and binders primarily on affinity metrics, neglecting evolutionary pressures that drive antigen editing, downregulation, isoform shifts, and glycosylation remodelling under s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7743debd-19f0-5f20-9ed2-7c3b0dfcefb7
DOI: 10.64898/2026.05.24.727464

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor DesignDOI 10.64898/2026.05.24.727464Read

AI supported in silico screening of chimeric antigen receptor therapy targetsSemantic proximity Read

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptorsSemantic proximity Read

Computational structural optimization enhances IL13Rα2 – B7-H3 tandem CAR T cells to overcome antigen-heterogeneity-mediated tumor escapeSemantic proximity Read

High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface AntigensSemantic proximity Read

Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapiesSemantic proximity Read

A high throughput bispecific antibody discovery pipelineSemantic proximity Read

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule FrameworkSemantic proximity Read

De novo design of therapeutic scFvs and multi-specific engagers from sequence aloneSemantic proximity Read

AI-Guided CAR Designs and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen EscapeSemantic proximity Read

Computational modeling and optimization of peptide-based CAR-T cell receptors targeting CD19 for enhanced efficacy and minimized toxicitySemantic proximity Read

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastomaSemantic proximity Read

A practical workflow for CAR screening in primary T cells using fitness-guided design and mRNA electroporationSemantic proximity Read