Article

<i>De novo</i> protein design enables precise induction of functional antibodies <i>in vivo</i>

2019-06-28

Abstract excerpt

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines. Here, we present a novel protein design algorithm, termed TopoBuilder, with which we engineered epitope-focused im...

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Literature Corpus work: 9150bcb9-6d27-51f2-9c1a-d88ffa52277f
DOI: 10.1101/685867

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