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Article

Transcriptionally active enhancers in human cancer cells.

Molecular systems biology - 1 Jan 2021

Lidschreiber Katja, Jung Lisa A, von der Emde Henrik, Dave Kashyap, Taipale Jussi, Cramer Patrick, Lidschreiber Michael

Abstract excerpt

The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Here, we use transient transcriptome sequencing (TT-seq) to map thousands of transcriptionally active putative enhancers in fourteen human cancer cell lines covering seven types of cancer. These enhancers were associated with cell type-specific gene expression, enriched for genetic variants that predispose to cancer,...

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Share to Enhancer Elements, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

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Share to Sequence Analysis, RNA

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Source

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Identifiers

PMID: 33502116
DOI: 10.15252/msb.20209873
PMCID: PMC7838827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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