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Article

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

1 Apr 2018

Abstract excerpt

The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers....

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PMID: 29625054
DOI: 10.1016/j.cell.2018.03.027

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