Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers.

doi:10.1186/s40779-024-00539-2

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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers.

Military Medical Research - 11 Jun 2024

Cai Yi-Min, Lu Ze-Qun, Li Bin, Huang Jin-Yu, Zhang Ming, Chen Can, Fan Lin-Yun, Ma Qian-Ying, He Chun-Yi, Chen Shuo-Ni, Jiang Yuan, Li Yan-Min, Ning Cai-Bo, Zhang Fu-Wei, Wang Wen-Zhuo, Liu Yi-Zhuo, Zhang Heng, Jin Meng, Wang Xiao-Yang, Han Jin-Xin, Xiong Zhen, Cai Ming, Huang Chao-Qun, Yang Xiao-Jun, Zhu Xu, Zhu Ying, Miao Xiao-Ping, Zhang Shao-Kai, Wei Yong-Chang, Tian Jian-Bo

Abstract excerpt

BACKGROUND: Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic basis of eRNA expression may elucidate the molecular mechanisms underlying cancers. METHODS: Initially, a comprehensive analysis of eRNA quantitative trait loci (eRNAQTLs) was performed in The...

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PMID: 38863031
DOI: 10.1186/s40779-024-00539-2
PMCID: PMC11165858

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