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Article

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.

Nature communications - 7 Feb 2017

Cohen Andrea J, Saiakhova Alina, Corradin Olivia, Luppino Jennifer M, Lovrenert Katreya, Bartels Cynthia F, Morrow James J, Mack Stephen C, Dhillon Gursimran, Beard Lydia, Myeroff Lois, Kalady Matthew F, Willis Joseph, Bradner James E, Keri Ruth A, Berger Nathan A, Pruett-Miller Shondra M, Markowitz Sanford D, Scacheri Peter C

Abstract excerpt

In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specimens. Using normal colonic crypt epithelium as a comparator, we identify enhancers with recurrently gained or lost activity across CRC...

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Identifiers

PMID: 28169291
DOI: 10.1038/ncomms14400
PMCID: PMC5309719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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