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Article

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer.

Cancer cell - 9 Nov 2020

Chen Han, Liang Han

Abstract excerpt

Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical samples remains challenging, especially for super-enhancers. Enhancer activities can be inferred from enhancer RNA (eRNA) signals, which requires enhancer transcription loci definition. Only a small proportion of human eRNA loci has been precisely identified, limiting investigations of enhancer-mediated oncogenic...

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Share to Databases, Genetic
Share to Enhancer Elements, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Analysis, RNA

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Identifiers

PMID: 33007258
DOI: 10.1016/j.ccell.2020.08.020
PMCID: PMC7658066

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