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Article

Molecular-defined clonal evolution in patients with classical myeloproliferative neoplasms.

British journal of haematology - 1 Jul 2023

Hinze Anna, Rinke Jenny, Crodel Carl C, Möbius Susanne, Schäfer Vivien, Heidel Florian H, Hochhaus Andreas, Ernst Thomas

Abstract excerpt

Classical myeloproliferative neoplasms (MPNs) are characterized by distinct clinical phenotypes. The discovery of driver mutations in JAK2, CALR and MPL genes provided new insights into their pathogenesis. Next-generation sequencing (NGS) identified additional somatic mutations, most frequently in epigenetic modulator genes. In this study, a cohort of 95 MPN patients was genetically characterized using targeted...

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Identifiers

PMID: 37139709
DOI: 10.1111/bjh.18834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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