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Article

Evolution of myeloproliferative neoplasms from normal blood stem cells.

Haematologica - 1 Apr 2025

Hormoz Sahand, Sankaran Vijay G, Mullally Ann

Abstract excerpt

Over the course of the last decade, genomic studies in the context of normal human hematopoiesis have provided new insights into the early pathogenesis of myeloproliferative neoplasms (MPN). A preclinical phase of MPN, termed clonal hematopoiesis was identified and subsequent lineage tracing studies revealed a multi-decade long time interval from acquisition of an MPN phenotypic driver mutation in a hematopoietic...

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Identifiers

PMID: 39633553
DOI: 10.3324/haematol.2023.283951
PMCID: PMC11959262

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